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Several PD catheter-related interventions (catheter designs, surgical insertion approaches, and connection methods) have been purported to reduce the risk of peritonitis in PD.

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Those authors demonstrated that, in nearly all samples (with or without peritonitis), a parallel increase occurred in both the procoagulant and fibrinolytic pathways, suggesting that heparin was not required in those patients even during peritonitis ().

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Rapid screening by means of the polymerase chain reaction (PCR), which largely overcomes these logistical problems, has been studied in cardiac-surgery patients for more than a decade.

HD patients demonstrated that 3-times-weekly application of standardized antimicrobial honey to the HD catheter exit site was safe, inexpensive, and effective, and that it resulted in a rate of catheter-associated infections comparable to that obtained with topical mupirocin prophylaxis ().

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Immediately after providing written informed consent, the patient was assigned to either the active treatment or the placebo according to the randomization list, and the first dose of nasal ointment was applied.

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Decolonization commonly involves a multiday regimen of intranasal mupirocin and chlorhexidine bathing.

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Although that observation in a nonrandomized study was felt not to provide sufficient evidence to generally advise against the use of a first-generation cephalosporin in PD-associated peritonitis, we do not recommend repeated use of such agents in relapsing peritonitis.

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