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Many patients will need to be on two or more medications so in addition to a diuretic; a patient may be started on an ACE inhibitor such as lisinopril, an ARB such as losartan (Cozaar), a beta-blocker such as metoprolol (Lopressor), or calcium channel blocker such as amlodipine (Norvasc).

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Thiazide diuretic works extremely well in controlling hypertension; the benefit is through the synergistic effect the two drugs have on the renin-angiotension-aldostersone mechanism.

These disturbances have sometimes been manifest as one or more of dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, nausea, and vomiting.

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See Geriatric Patients under Dosage and Administration and see Special Populations under Pharmacokinetics.

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Updated guidelines for management of high blood pressure: recommendations, review, and responsibility.

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Tetracycline and Other Drugs That Interact with Magnesium: Simultaneous administration of tetracycline with quinapril reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets.

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Calcium channel blockers may have some side effects, the most common of which are constipation, nausea, headache, rash, edema (swelling of the legs with fluid), low blood pressure, drowsiness, and dizziness.

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On the one hand, the calcium-channel blocker lowered blood pressure more significantly than the ARB, especially initially: in the first few months of the study, amlodipine lowered systolic blood pressure by 4 mm Hg more than valsartan, while beyond six months, the extra decrease in systolic blood pressure was a less dramatic but still significant 2 mm Hg.

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