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This difference is most likely due to the reduction in renal function with age, since pramipexole clearance is correlated with renal function, as measured by creatinine clearance.
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R- of pramipexole (which has much lower affinity to the dopamine receptors when compared to the S-isomer) side-by-side with the effects of the S-isomer.
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CSF analysis of certain neurotransmitter metabolites can help distinguish between all of these conditions and each of these conditions requires separate therapies.
Use of antidepressants, such as serotonin reuptake inhibitors, has been shown to exacerbate symptoms of RLS as well as increase periodic limb movements in sleep.
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The doctor will also check for tremor symmetry, any sensory loss, weakness or muscle atrophy, or decreased reflexes.
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However, a healthcare provider will consider several factors (such as current symptoms, mental and emotional state, and other medications) before recommending a specific treatment plan.
Pramipexole's effects were noticed quickly due to it's prominent effects on dopamine.
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By lowering prolactin through an increase in dopamine, Pramipexole can directly reduce the refractory period resulting in the ability to perform sexually more frequently.
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Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs (especially CNS depressants or alcohol), as well as any concomitant illnesses.
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One study found that hyperphosphatemia, anxiety, and a high degree of emotion-oriented coping with stress were independently related to the presence of RLS in patients with uremia who were undergoing hemodialysis.
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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
The electrodiagnostic tests showed no abnormal activities when the patient was at rest.
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For the purposes of selecting the appropriate treatment, you should determine if your symptoms are intermittent, daily, or refractory to treatment.
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The condition is difficult to treat, although the drug baclofen, combined with either clonazepam or carbamazepine, has shown some success.
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Neuroleptic Malignant Syndrome (NMS): A potentially fatal complex sometimes referred to as NMS has been associated with the administration of antipsychotic drugs.
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None the less, the large majority of users will experience at least some degree of sexual dysfunction, with a smaller portion suffering complete impotence.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
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Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition.
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Similarly prevalent is the "wearing-off" phenomenon, the most common type of motor fluctuation, in which the duration of effect with each levodopa dose progressively shortens over time.